Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 2/20 | 0.56 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.47 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728601 | 0.84 | TYR (0.54) | TYRTRIM24TRIM33PIK3CDPIK3CA | |
| SCHEMBL14940724 | 0.80 | ALDH1A1 (0.41) | TYRERN1ALDH1A1MAPTKDM4E | |
| SCHEMBL29446225 | 0.79 | TYR (0.52) | TYRTRIM24TRIM33PIK3CDPIK3CA | |
| SCHEMBL1001895 | 0.79 | TYR (0.52) | TYRTRIM24TRIM33PIK3CDPIK3CA | |
| SCHEMBL5147106 | 0.79 | TYR (0.53) | TYRTRIM24TRIM33PIK3CDPIK3CA | |
| SCHEMBL14941561 | 0.76 | ALDH1A1 (0.62) | TYRTRIM24TRIM33PRKDCERN1 | |
| SCHEMBL9427138 | 0.76 | TYR (0.49) | TYRTRIM24TRIM33ALDH1A1MAPT | |
| SCHEMBL14940654 | 0.76 | ALDH1A1 (0.43) | TYRTRIM24TRIM33ERN1ALDH1A1 | |
| SCHEMBL14852924 | 0.76 | TYR (0.45) | TYRTRIM24TRIM33PIK3CDPIK3CA | |
| SCHEMBL56902 | 0.75 | ALDH1A1 (0.61) | ALDH1A1MAPTKDM4EMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068592-A1 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2013-05-16 | — | — | WO | disclosed |