Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 3/20 | 0.49 |
| ▸ | RXRA | P19793 | 2/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2262192 | 0.96 | RXRA (0.49) | NR1H3RXRANR1H2ARKDM4E | |
| SCHEMBL2266432 | 0.93 | RXRA (0.54) | NR1H3RXRANR1H2ARKDM4E | |
| SCHEMBL2264071 | 0.91 | NR1H2 (0.49) | NR1H3RXRANR1H2ARKDM4E | |
| SCHEMBL2266370 | 0.91 | NR1H2 (0.54) | NR1H3RXRANR1H2ARKDM4E | |
| SCHEMBL2262033 | 0.89 | RXRA (0.50) | NR1H3RXRANR1H2ARKDM4E | |
| SCHEMBL2265896 | 0.87 | NR1H2 (0.51) | NR1H3RXRANR1H2KDM4EHPGD | |
| SCHEMBL2263764 | 0.86 | RXRA (0.61) | NR1H3RXRANR1H2ARKDM4E | |
| SCHEMBL2260085 | 0.86 | RXRA (0.55) | NR1H3RXRANR1H2ARKDM4E | |
| SCHEMBL2265442 | 0.85 | RXRA (0.51) | NR1H3RXRANR1H2ARKDM4E | |
| SCHEMBL2265446 | 0.85 | MRGPRX4 (0.48) | NR1H3RXRANR1H2ARXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465869-B1 | MODULATORS OF LXR | EXELIXIS PATENT CO LLC (US) | 2013-05-15 | — | — | EP | disclosed |