Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.51 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.51 |
| ▸ | RXRA | P19793 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2386372 | 0.93 | NR1H2 (0.52) | NR1H2NR1H3RXRAARMEN1 | |
| SCHEMBL2388648 | 0.93 | RXRA (0.53) | NR1H2NR1H3RXRAKDM4EGLA | |
| SCHEMBL2389162 | 0.92 | NR1H2 (0.51) | NR1H2NR1H3RXRAKDM4EGLA | |
| SCHEMBL2391088 | 0.91 | NR1H2 (0.51) | NR1H2NR1H3RXRAKDM4EGLA | |
| SCHEMBL2263493 | 0.91 | NR1H2 (0.62) | NR1H2NR1H3RXRAKDM4EGLA | |
| SCHEMBL2389952 | 0.90 | NR1H2 (0.48) | NR1H2NR1H3RXRAARMEN1 | |
| SCHEMBL2262770 | 0.90 | NR1H2 (0.53) | NR1H2NR1H3RXRAKDM4EGLA | |
| SCHEMBL2387552 | 0.90 | NR1H2 (0.52) | NR1H2NR1H3RXRAKDM4EGLA | |
| SCHEMBL2387075 | 0.90 | NR1H2 (0.49) | NR1H2NR1H3RXRAKDM4EGLA | |
| SCHEMBL2385089 | 0.89 | NR1H2 (0.51) | NR1H2NR1H3RXRAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465869-B1 | MODULATORS OF LXR | EXELIXIS PATENT CO LLC (US) | 2013-05-15 | — | — | EP | disclosed |