Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.47 |
| ▸ | RXRA | P19793 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264361 | 0.92 | NR1H2 (0.49) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL2264755 | 0.88 | NR1H2 (0.52) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL2262884 | 0.88 | NR1H2 (0.52) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL2266112 | 0.87 | NR1H2 (0.56) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL4904761 | 0.87 | NR1H2 (0.52) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL2264745 | 0.85 | NR1H2 (0.49) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL2264167 | 0.84 | NR1H2 (0.51) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL4906529 | 0.84 | NR1H2 (0.48) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL2268665 | 0.84 | NR1H2 (0.50) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL4907487 | 0.84 | RXRA (0.66) | NR1H2NR1H3RXRAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465869-B1 | MODULATORS OF LXR | EXELIXIS PATENT CO LLC (US) | 2013-05-15 | — | — | EP | disclosed |