Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2326884 | 0.83 | ALDH1A1 (0.54) | ALDH1A1MAPTKDM4EF2LMNA | |
| SCHEMBL3766778 | 0.82 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4EF2LMNA | |
| SCHEMBL30747061 | 0.82 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4EF2LMNA | |
| SCHEMBL19050707 | 0.80 | ALDH1A1 (0.51) | ALDH1A1MAPTKDM4EF2LMNA | |
| SCHEMBL7708846 | 0.80 | ALDH1A1 (0.51) | ALDH1A1MAPTKDM4EF2LMNA | |
| SCHEMBL19168586 | 0.78 | CYP3A4 (0.45) | ALDH1A1MAPTKDM4EF2POLB | |
| SCHEMBL15000817 | 0.78 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4EF2LMNA | |
| SCHEMBL29173941 | 0.78 | ALDH1A1 (0.50) | ALDH1A1MAPTKDM4EF2LMNA | |
| SCHEMBL11782542 | 0.77 | ALDH1A1 (0.49) | ALDH1A1MAPTKDM4EF2LMNA | |
| SCHEMBL8661206 | 0.77 | ALDH1A1 (0.49) | ALDH1A1MAPTKDM4EF2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2592082-A1 | Heteroaryl amide analogues as p2x7 antagonists | H. Lundbeck A/S (DK) | 2013-05-15 | — | — | EP | disclosed |