Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.52 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.51 |
| ▸ | PDE9A | O76083 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14944176 | 0.96 | RXRA (0.56) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL14944224 | 0.95 | RXRA (0.57) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2265833 | 0.94 | KDM4E (0.55) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2263602 | 0.92 | RXRA (0.52) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL14944222 | 0.89 | RXRA (0.51) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2263428 | 0.88 | KDM4E (0.54) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL6220439 | 0.88 | RXRA (0.48) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2262871 | 0.88 | RXRA (0.59) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2262221 | 0.88 | RXRA (0.59) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL14944175 | 0.86 | RXRA (0.57) | RXRANR1H2NR1H3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465869-B1 | MODULATORS OF LXR | EXELIXIS PATENT CO LLC (US) | 2013-05-15 | — | — | EP | disclosed |