SCHEMBL14944245

SCHEMBL14944245

N#Cc1c(C(F)(F)F)cc(-c2ccc(OCc3ccccc3)cc2)n(Cc2ccccc2)c1=O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 2/20 0.60
NR1H2 P55055 2/20 0.60
NR1H3 Q13133 2/20 0.60
KDM4E B2RXH2 2/20 0.49
HPGD P15428 2/20 0.49
ALDH1A1 P00352 1/20 0.49
PPARG P37231 1/20 0.49
NCOA2 Q15596 1/20 0.49
NCOA1 Q15788 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49
NCOA3 Q9Y6Q9 1/20 0.49
GRM2 Q14416 1/20 0.45
GSTP1 P09211 1/20 0.43
MAOB P27338 4/20 0.43
AR P10275 3/20 0.42
EGLN2 Q96KS0 1/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.41
BACE1 P56817 1/20 0.41
MGAT2 Q10469 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2266370 0.90 NR1H2 (0.54) RXRANR1H2NR1H3KDM4EHPGD
SCHEMBL2266432 0.90 RXRA (0.54) RXRANR1H2NR1H3KDM4EHPGD
SCHEMBL14944242 0.89 RXRA (0.74) RXRANR1H2NR1H3KDM4EHPGD
SCHEMBL2387661 0.89 RXRA (0.59) RXRANR1H2NR1H3KDM4EHPGD
SCHEMBL12390674 0.89 RXRA (0.58) RXRANR1H2NR1H3KDM4EHPGD
SCHEMBL2388745 0.88 RXRA (0.67) RXRANR1H2NR1H3KDM4EHPGD
SCHEMBL14944175 0.88 RXRA (0.57) RXRANR1H2NR1H3KDM4EHPGD
SCHEMBL4904563 0.88 RXRA (0.80) RXRANR1H2NR1H3KDM4EHPGD
SCHEMBL2262221 0.88 RXRA (0.59) RXRANR1H2NR1H3KDM4EHPGD
SCHEMBL2263886 0.87 RXRA (0.59) RXRANR1H2NR1H3KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1465869-B1 MODULATORS OF LXR EXELIXIS PATENT CO LLC (US) 2013-05-15 EP disclosed