Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Bekanamycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.88 |
| ▸ | MEN1 | O00255 | 2/20 | 0.88 |
| ▸ | GJA1 | P17302 | 1/20 | 0.88 |
| ▸ | GJB2 | P29033 | 1/20 | 0.88 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.88 |
| ▸ | MAPT | P10636 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | LRAT | O95237 | 1/20 | 0.72 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bekanamycin SCHEMBL16174013 | 1.00 | ALOX15 (1.00) | ALOX15KDM4ETSHRMEN1GJA1 | |
| Bekanamycin SCHEMBL9250504 | 1.00 | ALOX15 (1.00) | ALOX15KDM4ETSHRMEN1GJA1 | |
| Bekanamycin SCHEMBL19917387 | 1.00 | ALOX15 (1.00) | ALOX15KDM4ETSHRMEN1GJA1 | |
| Bekanamycin SCHEMBL12535725 | 1.00 | ALOX15 (1.00) | ALOX15KDM4ETSHRMEN1GJA1 | |
| Bekanamycin SCHEMBL17265214 | 1.00 | ALOX15 (1.00) | ALOX15KDM4ETSHRMEN1GJA1 | |
| Bekanamycin SCHEMBL23879718 | 1.00 | ALOX15 (1.00) | ALOX15KDM4ETSHRMEN1GJA1 | |
| Bekanamycin SCHEMBL16174041 | 1.00 | ALOX15 (1.00) | ALOX15KDM4ETSHRMEN1GJA1 | |
| Bekanamycin SCHEMBL13018550 | 1.00 | ALOX15 (1.00) | ALOX15KDM4ETSHRMEN1GJA1 | |
| Bekanamycin SCHEMBL12553422 | 1.00 | ALOX15 (1.00) | ALOX15KDM4ETSHRMEN1GJA1 | |
| Bekanamycin SCHEMBL158427 | 1.00 | ALOX15 (1.00) | ALOX15KDM4ETSHRMEN1GJA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150612-B2 | RNA targeting compounds and methods for making and using same | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2015-10-06 | — | — | US | disclosed |
| EP-2591795-A1 | RNA targeting compounds and methods for making and using same | The Research Foundation Of State University Of New York (US) | 2013-05-15 | — | — | EP | disclosed |