Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 18/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL303565 | 0.81 | SCN9A (0.60) | SCN9ASCN10ASCN5A | |
| SCHEMBL476793 | 0.77 | CYP1A2 (0.51) | MKNK1MKNK2SCN9A | |
| Hydrochloric Acid SCHEMBL304059 | 0.76 | CYP1A2 (0.50) | MKNK1MKNK2SCN9A | |
| SCHEMBL14688369 | 0.75 | CYP11B1 (0.40) | MKNK1MKNK2DDB1CRBN | |
| SCHEMBL305521 | 0.72 | SCN9A (0.48) | MKNK1MKNK2SCN9ASCN10A | |
| SCHEMBL303982 | 0.71 | CYP17A1 (0.56) | MKNK1MKNK2 | |
| SCHEMBL305462 | 0.71 | CYP1A2 (0.49) | MKNK1MKNK2SCN9ADDB1CRBN | |
| SCHEMBL4953525 | 0.69 | MKNK1 (0.44) | MKNK1MKNK2DDB1CRBN | |
| SCHEMBL14688616 | 0.68 | PDE10A (0.43) | — | |
| SCHEMBL4573821 | 0.68 | MAPK14 (0.50) | MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869003-B1 | INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS | GLAXO GROUP LTD (GB) | 2013-05-15 | — | — | EP | disclosed |