Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14419426 | 0.87 | MAPT (0.52) | ALDH1A1TSHRCYP3A4RECQLMAPT | |
| SCHEMBL3721960 | 0.86 | MAPT (0.64) | ALDH1A1TSHRCYP3A4RECQLMAPT | |
| SCHEMBL246285 | 0.86 | MAPT (0.54) | ALDH1A1TSHRCYP3A4RECQLMAPT | |
| SCHEMBL28674209 | 0.85 | MAPT (0.53) | ALDH1A1TSHRCYP3A4RECQLMAPT | |
| SCHEMBL13301370 | 0.83 | ALDH1A1 (0.49) | ALDH1A1TSHRCYP3A4RECQLMAPT | |
| SCHEMBL4228943 | 0.83 | MAPT (0.66) | ALDH1A1TSHRCYP3A4RECQLMAPT | |
| SCHEMBL30178231 | 0.83 | ALDH1A1 (0.49) | ALDH1A1TSHRCYP3A4RECQLMAPT | |
| SCHEMBL4257371 | 0.83 | MAPT (0.57) | ALDH1A1TSHRCYP3A4RECQLMAPT | |
| SCHEMBL16665240 | 0.82 | MAPT (0.50) | ALDH1A1TSHRCYP3A4RECQLMAPT | |
| SCHEMBL5465073 | 0.82 | MAPT (0.50) | ALDH1A1TSHRCYP3A4RECQLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470528-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | Novartis AG (CH) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011023773-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-03-03 | — | — | WO | disclosed |