Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | TPH1 | P17752 | 2/20 | 0.39 |
| ▸ | TPH2 | Q8IWU9 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14944673 | 0.83 | TLR7 (0.64) | TLR7ADORA1 | |
| SCHEMBL21581161 | 0.75 | TLR7 (0.55) | TLR7ADORA1 | |
| SCHEMBL20343835 | 0.75 | TLR7 (0.40) | TLR7ABHD6ADORA2AADORA1LOXL2 | |
| SCHEMBL21581162 | 0.73 | TLR7 (0.51) | TLR7ADORA1 | |
| SCHEMBL19423866 | 0.73 | TLR7 (0.63) | TLR7 | |
| SCHEMBL14944641 | 0.72 | TLR7 (0.50) | TLR7ADORA1 | |
| SCHEMBL20343750 | 0.69 | LOXL2 (0.38) | TLR7ADORA2AADORA1LOXL2YTHDC1 | |
| SCHEMBL14987126 | 0.69 | HTT (0.71) | ABHD6LOXL2IDO1MAPK10TSHR | |
| SCHEMBL19423908 | 0.69 | TLR7 (0.50) | TLR7ADORA1 | |
| SCHEMBL14944614 | 0.67 | TLR7 (0.51) | TLR7ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068438-A1 | PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN R&D IRELAND (IE) | 2013-05-16 | — | — | WO | disclosed |