Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 18/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYBB | P04839 | 1/20 | 0.44 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14931576 | 0.81 | NOX4 (0.58) | NOX4CYP3A4CYBBNOX1CYP2C8 | |
| SCHEMBL29523627 | 0.81 | NOX4 (0.58) | NOX4CYP3A4CYBBNOX1CYP2C8 | |
| SCHEMBL14931655 | 0.75 | NOX4 (0.72) | NOX4CYP3A4CYBBNOX1CYP2C8 | |
| SCHEMBL29523734 | 0.75 | NOX4 (0.72) | NOX4CYP3A4CYBBNOX1CYP2C8 | |
| SCHEMBL14931674 | 0.72 | NOX4 (0.51) | NOX4CYP3A4CYBBNOX1 | |
| SCHEMBL29523661 | 0.71 | NOX4 (0.69) | NOX4CYP3A4CYBBNOX1CYP2C8 | |
| SCHEMBL14931788 | 0.71 | NOX4 (0.69) | NOX4CYP3A4CYBBNOX1CYP2C8 | |
| SCHEMBL14931658 | 0.71 | NOX4 (0.50) | NOX4CYP3A4CYBBNOX1 | |
| SCHEMBL2214545 | 0.68 | NOX4 (0.81) | NOX4CYP3A4CYBBNOX1CYP2C8 | |
| SCHEMBL14931559 | 0.68 | NOX4 (0.73) | NOX4CYP3A4CYBBNOX1CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068972-A1 | NADPH OXIDASE 4 INHIBITORS AND USE THEREOF | Johann Wolfgang Goethe-Universität (DE) | 2013-05-16 | — | — | WO | disclosed |