Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10853833 | 0.99 | TBXAS1 (0.98) | TBXAS1 | |
| SCHEMBL10855281 | 0.91 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL10859489 | 0.87 | TBXAS1 (0.77) | TBXAS1 | |
| SCHEMBL10861539 | 0.79 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL10853043 | 0.77 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL11287283 | 0.77 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL10853495 | 0.76 | TBXAS1 (0.78) | TBXAS1 | |
| SCHEMBL10856261 | 0.76 | CYP19A1 (0.66) | TBXAS1 | |
| SCHEMBL10859911 | 0.76 | TBXAS1 (0.77) | TBXAS1 | |
| SCHEMBL10856956 | 0.75 | TBXAS1 (0.76) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4496572-A | Benzo-fused thromboxane synthetase inhibitors | PFIZER INC. (US) | 1985-01-29 | — | — | US | claimed |
| US-20160333343-A1 | Method of Treatment of Vascular Complications | THE HEART RESEARCH INSTITUTE LTD. (AU) | 2016-11-17 | — | — | US | disclosed |
| EP-2565275-B1 | Method of treatment of vascular complications using modulators of TRX and TRXNIP | HEART RES INST LTD (AU) | 2016-04-20 | — | — | EP | disclosed |
| EP-2565275-A1 | Method of treatment of vascular complications using modulators of TRX and TRXNIP | THE HEART RESEARCH INSTITUTE LIMITED (AU) | 2013-03-06 | — | — | EP | disclosed |
| US-20120058105-A1 | METHOD OF TREATMENT OF VASCULAR COMPLICATIONS | THE HEART RESEARCH INSTITUTE LTD (AU) | 2012-03-08 | — | — | US | disclosed |
| EP-0073663-B1 | THROMBOXANE SYNTHETASE INHIBITORS, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pfizer Limited (GB) | 1986-06-18 | — | — | EP | disclosed |
| US-4590200-A | NON-INHIBITION OF PROSTACYCLIN SYNTHETASE OR CYCLO-OXYGENASE | PFIZER INC. (US) | 1986-05-20 | — | — | US | disclosed |
| US-4496572-A | Benzo-fused thromboxane synthetase inhibitors | PFIZER INC. (US) | 1985-01-29 | — | — | US | disclosed |