Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.73 |
| ▸ | KDR | P35968 | 12/20 | 0.67 |
| ▸ | AXL | P30530 | 3/20 | 0.56 |
| ▸ | MERTK | Q12866 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | STK25 | O00506 | 1/20 | 0.52 |
| ▸ | CIT | O14578 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | MUSK | O15146 | 1/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | PAK3 | O75914 | 1/20 | 0.52 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17447792 | 0.97 | MET (0.67) | METKDRAXLMERTKFLT3 | |
| SCHEMBL10133670 | 0.87 | MET (0.71) | METKDRAXLMERTKPLK4 | |
| SCHEMBL21218132 | 0.84 | MET (0.75) | METKDRAXLMERTKPLK4 | |
| SCHEMBL29693453 | 0.84 | MET (1.00) | METKDRAXLMERTKPLK4 | |
| SCHEMBL371651 | 0.84 | MET (1.00) | METKDRAXLMERTKPLK4 | |
| SCHEMBL17447780 | 0.84 | MET (0.65) | METKDRAXLMERTKPLK4 | |
| SCHEMBL29693555 | 0.82 | MET (0.88) | METKDRAXLMERTKAURKA | |
| SCHEMBL4401230 | 0.82 | MET (0.88) | METKDRAXLMERTKAURKA | |
| SCHEMBL29693551 | 0.82 | MET (0.88) | METKDRAXLMERTKAURKA | |
| SCHEMBL4401193 | 0.82 | MET (0.88) | METKDRAXLMERTKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242991-B2 | Substituted fused heterocycles as c-Met tyrosine kinase inhibitors | BETTA PHARMACEUTICALS CO., LTD (CN) | 2016-01-26 | — | — | US | disclosed |
| US-20130123286-A1 | Novel Fused Heterocyclic Derivatives Useful as c-Met Tyrosine Kinase Inhibitors | BETTA PHARMACEUTICALS CO., LTD. (CN) | 2013-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123286-A1 | Novel Fused Heterocyclic Derivatives Useful as c-Met Tyrosine Kinase Inhibitors | MET, RET, ABL1 | MET 1/4885KDR 48/4885AXL 408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.