SCHEMBL14949150

SCHEMBL14949150

Cc1ccc(Cl)c(Cc2ccc(O[C@H]3CCOC3)cc2)c1

nearest known ligand 0.59

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 17/20 0.59
SLC5A1 P13866 10/20 0.59
PDE2A O00408 2/20 0.41
PDE10A Q9Y233 2/20 0.41
HRH3 Q9Y5N1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17859644 1.00 SLC5A2 (0.59) SLC5A2SLC5A1PDE2APDE10AHRH3
SCHEMBL17189332 0.88 SLC5A2 (0.59) SLC5A2SLC5A1PDE2APDE10A
SCHEMBL14949125 0.88 SLC5A2 (0.46) SLC5A2SLC5A1HRH3
SCHEMBL15682904 0.88 SLC5A2 (0.46) SLC5A2SLC5A1HRH3
SCHEMBL30830341 0.88 SLC5A2 (0.61) SLC5A2SLC5A1PDE2APDE10AHRH3
SCHEMBL14949153 0.88 SLC5A2 (0.46) SLC5A2SLC5A1HRH3
SCHEMBL19189964 0.87 SLC5A2 (0.60) SLC5A2SLC5A1PDE2APDE10AHRH3
SCHEMBL28981278 0.86 SLC5A2 (0.57) SLC5A2SLC5A1PDE2APDE10A
SCHEMBL28981279 0.86 SLC5A2 (0.57) SLC5A2SLC5A1PDE2APDE10A
SCHEMBL3465613 0.86 SLC5A2 (0.59) SLC5A2SLC5A1PDE2APDE10AHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3246324-A2 PHENYL C-GLUCOSIDE DERIVATIVE CONTAINING DEOXYGLUCOSE STRUCTURE, PREPARATION METHOD AND USES THEREOF Tianjin Institute Of Pharmaceutical Research (CN) 2017-11-22 EP disclosed
EP-2776449-B1 PROCESS FOR THE PREPARATION OF BETA-C-ARYL GLUCOSIDES SCINOPHARM TAIWAN LTD (TW) 2017-08-02 EP disclosed
US-20170057989-A1 PHENYL C-GLUCOSIDE DERIVATIVE CONTAINING DEOXYGLUCOSE STRUCTURE, PREPARATION METHOD AND USE THEREOF TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) 2017-03-02 US disclosed
US-9505734-B2 Phenyl C-glucoside derivative containing deoxyglucose structure, preparation method and use thereof TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) 2016-11-29 US disclosed
EP-2933250-A1 PHENYL C-GLUCOSIDE DERIVATIVE CONTAINING DEOXYGLUCOSE STRUCTURE, PREPARATION METHOD AND USE THEREOF Tianjin Institute Of Pharmaceutical Research (CN) 2015-10-21 EP disclosed
US-8802842-B2 Method for the preparation of a crystalline form BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-08-12 US disclosed
WO-2013068850-A2 PROCESS FOR THE PREPARATION OF β-C-ARYL GLUCOSIDES SCINOPHARM TAIWAN, LTD. (NA) 2013-05-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170057989-A1 PHENYL C-GLUCOSIDE DERIVATIVE CONTAINING DEOXYGLUCOSE STRUCTURE, PREPARATION METHOD AND USE THEREOF GCG, SLC5A1, DPP7 SLC5A2 6/4885SLC5A1 2/4885PDE2A 211/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.