Sugi Predict

Sugi Predict / Compounds / SCHEMBL14949191

SCHEMBL14949191

SCHEMBL14949191

Cc1cccc(Nc2nnc(-c3ccc(Oc4ccncc4S(N)(=O)=O)cc3)o2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA2 P00918 7/20 0.46
▸ CA1 P00915 6/20 0.46
▸ CA12 O43570 6/20 0.46
▸ CA9 Q16790 6/20 0.46
▸ MEN1 O00255 1/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ TP53 P04637 1/20 0.43
▸ MAPK1 P28482 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ GSK3B P49841 4/20 0.42
▸ CA14 Q9ULX7 2/20 0.42
▸ FLT1 P17948 2/20 0.42
▸ KDR P35968 2/20 0.42
▸ KDM4E B2RXH2 3/20 0.41
▸ ALDH1A1 P00352 1/20 0.41
▸ LMNA P02545 1/20 0.41
▸ GFER P55789 1/20 0.41
▸ MAOB P27338 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949319 0.92 CA2 (0.41) CA2CA1CA12CA9MEN1
SCHEMBL12336242 0.87 KDR (0.49) CA2CA1CA12CA9GSK3B
SCHEMBL14949189 0.81 MEN1 (0.54) MEN1NPC1TP53MAPK1RAB9A
SCHEMBL12336435 0.79 KDR (0.48) CA2CA1CA12CA9GSK3B
SCHEMBL12057529 0.78 MEN1 (0.52) MEN1NPC1TP53MAPK1RAB9A
SCHEMBL14949195 0.76 MEN1 (0.48) MEN1NPC1TP53MAPK1RAB9A
SCHEMBL14949194 0.74 NPC1 (0.48) MEN1NPC1TP53MAPK1RAB9A
SCHEMBL14949315 0.74 CA2 (0.41) CA2CA1CA12CA9CA14
SCHEMBL14949325 0.74 FLT1 (0.43) MEN1NPC1TP53MAPK1RAB9A
SCHEMBL14949193 0.74 KDR (0.51) MEN1NPC1TP53MAPK1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 CA2 3835/4885CA1 4732/4885CA12 4839/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 CA2 3835/4885CA1 4732/4885CA12 4839/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 CA2 3835/4885CA1 4732/4885CA12 4839/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.