Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 5/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.32 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395663 | 0.94 | NR1I2 (0.33) | NR1I2HTR2CKMT2AMAPTPPARG | |
| SCHEMBL14174239 | 0.88 | TDP1 (0.34) | NR1I2HTR2CKMT2AMAPTPPARG | |
| SCHEMBL2453654 | 0.86 | KDM4E (0.31) | NR1I2KMT2AMAPTPPARGPGR | |
| SCHEMBL3076794 | 0.86 | KDM4E (0.31) | NR1I2KMT2AMAPTPPARGPGR | |
| SCHEMBL12306379 | 0.84 | ALDH1A1 (0.33) | NR1I2HTR2CKMT2AMAPTPPARG | |
| SCHEMBL14185092 | 0.82 | NR1I2 (0.33) | NR1I2HTR2CKMT2AMAPTPPARG | |
| SCHEMBL14184951 | 0.80 | NR1I2 (0.31) | NR1I2PPARGPGRESR1PTGS2 | |
| SCHEMBL2450694 | 0.80 | NR1I2 (0.31) | NR1I2PPARGPGRESR1PTGS2 | |
| SCHEMBL3087170 | 0.80 | NR1I2 (0.31) | NR1I2PPARGPGRESR1PTGS2 | |
| SCHEMBL13457555 | 0.79 | KDM4E (0.32) | NR1I2KMT2AMAPTTDP1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445476-B2 | Carbacephem β-lactam antibiotics | ACHAOGEN, INC. (US) | 2013-05-21 | — | — | US | disclosed |