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Sugi Predict / Compounds / SCHEMBL14949334

SCHEMBL14949334

SCHEMBL14949334

COc1ccc2c(Oc3cccc(-c4nnc(Nc5cccc(C)c5)[nH]4)c3)ncnc2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 3/20 0.46
▸ KDR P35968 7/20 0.44
▸ BRAF P15056 4/20 0.43
▸ RAF1 P04049 3/20 0.43
▸ EGFR P00533 4/20 0.43
▸ CLK4 Q9HAZ1 2/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ USP2 O75604 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ CYP1A2 P05177 1/20 0.40
▸ CYP3A4 P08684 1/20 0.40
▸ CYP2C9 P11712 1/20 0.40
▸ TSHR P16473 1/20 0.40
▸ MAPK1 P28482 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ RET P07949 1/20 0.40
▸ SRC P12931 1/20 0.40
▸ TRPA1 O75762 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949202 0.93 CSF1R (0.50) CSF1RKDRBRAFRAF1EGFR
SCHEMBL14949342 0.90 EGFR (0.53) KDRBRAFRAF1EGFRRET
SCHEMBL12336530 0.88 BRAF (0.50) CSF1RKDRBRAFRAF1EGFR
SCHEMBL14949313 0.86 KDR (0.46) CSF1RKDRPDGFRBFLT3PDGFRA
SCHEMBL14949213 0.83 EGFR (0.54) CSF1RKDRBRAFRAF1EGFR
SCHEMBL14949314 0.83 TTBK1 (0.49) KDRBRAFEGFRTRPA1MAPK14
SCHEMBL14949369 0.82 HTT (0.40) MEN1TSHRMAPK1KMT2AABCG2
SCHEMBL14949358 0.81 KDR (0.38) KDRBRAFRAF1EGFRCLK4
SCHEMBL12336401 0.81 BRAF (0.53) CSF1RKDRBRAFRAF1EGFR
SCHEMBL14949353 0.81 KDR (0.45) KDREGFRPDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 CSF1R 2451/4885KDR 533/4885BRAF 39/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 CSF1R 2451/4885KDR 533/4885BRAF 39/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 CSF1R 2451/4885KDR 533/4885BRAF 39/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.