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SCHEMBL14949349

SCHEMBL14949349

Cc1cccc(Nc2nnc(-c3cccc(Oc4cc(SC(C)(C)C)nc(N)n4)c3)[nH]2)c1

nearest known ligand 0.32

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 1/20 0.32
▸ RAB9A P51151 1/20 0.32
▸ NOD1 Q9Y239 1/20 0.32
▸ TP53 P04637 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ LMNA P02545 1/20 0.31
▸ TSHR P16473 1/20 0.31
▸ NUDT1 P36639 1/20 0.31
▸ PDGFRB P09619 1/20 0.31
▸ KIT P10721 1/20 0.31
▸ PDGFRA P16234 1/20 0.31
▸ CDK11B P21127 1/20 0.31
▸ FLT3 P36888 1/20 0.31
▸ CDKL2 Q92772 1/20 0.31
▸ ADORA2A P29274 1/20 0.30
▸ CCR4 P51679 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949297 0.92 PDGFRB (0.37) NPC1RAB9ANOD1TP53MAPT
SCHEMBL12336540 0.89 PDGFRB (0.42) MAPTLMNAPDGFRBKITPDGFRA
SCHEMBL14949316 0.86 RAB9A (0.36) NPC1RAB9ANOD1TP53MAPT
SCHEMBL14949332 0.86 RAB9A (0.38) NPC1RAB9ANOD1TP53MAPT
SCHEMBL14949362 0.86 PDGFRB (0.40) PDGFRBKITPDGFRACDK11BFLT3
SCHEMBL14949331 0.83 RAB9A (0.39) NPC1RAB9ANOD1TP53MAPT
SCHEMBL14949368 0.83 RAB9A (0.36) NPC1RAB9ANOD1TP53MAPT
SCHEMBL14949352 0.83 PDGFRB (0.35) NPC1RAB9ANOD1TP53MAPT
SCHEMBL14949309 0.82 ROCK1 (0.40) NPC1RAB9ANOD1PDGFRBKIT
SCHEMBL12336492 0.81 PDGFRB (0.50) MAPTLMNAPDGFRBKITPDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 NPC1 3866/4885RAB9A 1281/4885NOD1 4086/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 NPC1 3866/4885RAB9A 1281/4885NOD1 4086/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 NPC1 3866/4885RAB9A 1281/4885NOD1 4086/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.