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Sugi Predict / Compounds / SCHEMBL14949356

SCHEMBL14949356

SCHEMBL14949356

CCOc1nc(N)cc(Oc2cccc(-c3nnc(Nc4cccc(C)c4)[nH]3)c2)n1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CDK8 P49336 1/20 0.34
▸ PDGFRB P09619 1/20 0.33
▸ KIT P10721 1/20 0.33
▸ PDGFRA P16234 1/20 0.33
▸ CDK11B P21127 1/20 0.33
▸ FLT3 P36888 1/20 0.33
▸ CDKL2 Q92772 1/20 0.33
▸ SYK P43405 2/20 0.33
▸ AURKB Q96GD4 1/20 0.32
▸ MAP4K4 O95819 1/20 0.32
▸ NOTUM Q6P988 1/20 0.32
▸ TP53 P04637 2/20 0.32
▸ ALDH1A1 P00352 2/20 0.32
▸ MAPT P10636 2/20 0.32
▸ SMN1; SMN2 Q16637 2/20 0.32
▸ NPC1 O15118 2/20 0.32
▸ TTBK1 Q5TCY1 1/20 0.32
▸ TTBK2 Q6IQ55 1/20 0.32
▸ ALOX12 P18054 1/20 0.32
▸ CCR6 P51684 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949266 0.92 PDGFRB (0.40) CDK8PDGFRBKITPDGFRACDK11B
SCHEMBL14949363 0.91 SYK (0.34) CDK8PDGFRBKITPDGFRACDK11B
SCHEMBL14949341 0.90 MEN1 (0.37) CDK8PDGFRBKITPDGFRACDK11B
SCHEMBL12336423 0.89 PDGFRB (0.44) CDK8PDGFRBKITPDGFRACDK11B
SCHEMBL14949376 0.88 PDGFRB (0.34) CDK8PDGFRBKITPDGFRACDK11B
SCHEMBL14949345 0.88 NPC1 (0.34) CDK8PDGFRBKITPDGFRACDK11B
SCHEMBL14949378 0.88 SYK (0.37) FLT3SYKAURKBTP53ALDH1A1
SCHEMBL14949331 0.88 RAB9A (0.39) CDK8SYKMAP4K4NOTUMTP53
SCHEMBL14949316 0.87 RAB9A (0.36) CDK8PDGFRBKITPDGFRACDK11B
SCHEMBL14949352 0.87 PDGFRB (0.35) CDK8PDGFRBKITPDGFRACDK11B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 CDK8 49/4885PDGFRB 497/4885KIT 540/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 CDK8 49/4885PDGFRB 497/4885KIT 540/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 CDK8 49/4885PDGFRB 497/4885KIT 540/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.