Sugi Predict

Sugi Predict / Compounds / SCHEMBL14949366

SCHEMBL14949366

SCHEMBL14949366

Cc1cccc(Nc2nnc(-c3cccc(Oc4cncc5ccccc45)c3)[nH]2)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 4/20 0.40
▸ MAPT P10636 6/20 0.37
▸ ABCB1 P08183 2/20 0.37
▸ ABCG2 Q9UNQ0 2/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ MEN1 O00255 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ MET P08581 1/20 0.35
▸ MAP3K8 P41279 1/20 0.35
▸ TP53 P04637 3/20 0.34
▸ NR1I3 Q14994 1/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ ABL1 P00519 1/20 0.34
▸ BCR P11274 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP2C9 P11712 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ FLT1 P17948 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949217 0.91 KDR (0.41) KDRMAPTABCB1ABCG2SMN1; SMN2
SCHEMBL12336735 0.86 ABCG2 (0.40) ABCG2TP53CYP1A2CYP2C9CYP2C19
SCHEMBL14949350 0.83 MAPT (0.43) KDRMAPTABCB1ABCG2SMN1; SMN2
SCHEMBL14949326 0.81 MAPT (0.42) KDRMAPTABCB1ABCG2SMN1; SMN2
SCHEMBL14949333 0.81 KDR (0.40) KDRMAPTABCB1ABCG2SMN1; SMN2
SCHEMBL14949321 0.81 KDR (0.46) KDRMAPTABCB1ABCG2SMN1; SMN2
SCHEMBL14949337 0.81 ABL1 (0.35) KDRMAPTMEN1KMT2ATP53
SCHEMBL14949702 0.80 KDR (0.41) KDRMAPTABCB1ABCG2SMN1; SMN2
SCHEMBL14949317 0.80 KMT2A (0.40) KDRMAPTABCG2SMN1; SMN2MEN1
SCHEMBL12336229 0.78 PDGFRB (0.40) KDRABCG2MAP3K8TP53BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 KDR 533/4885MAPT 4114/4885ABCB1 3063/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 KDR 533/4885MAPT 4114/4885ABCB1 3063/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 KDR 533/4885MAPT 4114/4885ABCB1 3063/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.