Sugi Predict

Sugi Predict / Compounds / SCHEMBL14949337

SCHEMBL14949337

SCHEMBL14949337

Cc1cccc(Nc2nnc(-c3cccc(Oc4cncnc4)c3)[nH]2)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 2/20 0.35
▸ BCR P11274 1/20 0.35
▸ CDK8 P49336 1/20 0.35
▸ KDR P35968 2/20 0.35
▸ FLT1 P17948 1/20 0.35
▸ FLT4 P35916 1/20 0.35
▸ CYP1A2 P05177 2/20 0.35
▸ CYP3A4 P08684 2/20 0.35
▸ CYP2D6 P10635 2/20 0.35
▸ CYP2C19 P33261 2/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ GRM5 P41594 2/20 0.35
▸ XDH P47989 1/20 0.35
▸ SLC22A12 Q96S37 1/20 0.35
▸ TTBK1 Q5TCY1 1/20 0.35
▸ TTBK2 Q6IQ55 1/20 0.35
▸ EGFR P00533 1/20 0.34
▸ ABL2 P42684 1/20 0.34
▸ KIT P10721 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14949317 0.88 KMT2A (0.40) ABL1BCRKDRFLT1MAPK1
SCHEMBL12336582 0.84 KIF11 (0.41) CDK8KDRTTBK1EGFR
SCHEMBL14949365 0.84 ABL1 (0.37) ABL1BCRCDK8KDRFLT1
SCHEMBL14949358 0.82 KDR (0.38) ABL1KDRCYP1A2CYP3A4CYP2D6
SCHEMBL14949347 0.82 KMT2A (0.38) ABL1BCRKDRFLT1CYP1A2
SCHEMBL14949311 0.82 CDK8 (0.40) ABL1BCRCDK8KDRFLT1
SCHEMBL14949366 0.81 KDR (0.40) ABL1BCRKDRFLT1FLT4
SCHEMBL14949307 0.81 EGFR (0.39) ABL1CDK8KDRFLT1FLT4
SCHEMBL14949566 0.80 NPY5R (0.42) ABL1BCRGRM5TTBK1TTBK2
SCHEMBL14949310 0.80 PTGS1 (0.37) ABL1BCRKDRCYP1A2KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2016-04-07 — — US disclosed
US-9212151-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-12-15 — — US disclosed
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. 2015-06-11 — — US disclosed
US-8957216-B2 Heterocyclic compounds useful for kinase inhibition AMITECH THERAPEUTIC SOLUTIONS, INC. (US) 2015-02-17 — — US disclosed
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION AMITECH THERAPEUTIC SOLUTIONS INC (US) 2013-05-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130123284-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR KINASE INHIBITION MAP4K2, MAP3K20, MAP3K19 ABL1 41/4885BCR 496/4885CDK8 49/4885
US-20150158828-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 ABL1 41/4885BCR 496/4885CDK8 49/4885
US-20160096824-A1 Heterocyclic Compounds Useful for Kinase Inhibition MAP4K2, MAP3K20, MAP3K19 ABL1 41/4885BCR 496/4885CDK8 49/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.