Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 2/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.51 |
| ▸ | GPR3 | P46089 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12817725 | 0.80 | LIMK1 (0.59) | LIMK1ROCK1 | |
| SCHEMBL20457808 | 0.79 | GPR3 (0.45) | LIMK1CDK5CDK5R1GPR3ROCK1 | |
| SCHEMBL17740734 | 0.79 | GPR3 (0.45) | LIMK1CDK5CDK5R1GPR3HRH4 | |
| SCHEMBL17109969 | 0.79 | GPR3 (0.45) | LIMK1CDK5CDK5R1GPR3ROCK1 | |
| SCHEMBL16906050 | 0.79 | GPR3 (0.45) | LIMK1CDK5CDK5R1GPR3HRH4 | |
| SCHEMBL12818763 | 0.77 | HRH4 (0.47) | LIMK1CDK5CDK5R1HRH4CLK1 | |
| SCHEMBL16902379 | 0.76 | NPC1 (0.46) | LIMK1CDK5CDK5R1GPR3MAPT | |
| SCHEMBL14629295 | 0.75 | GPR3 (0.41) | LIMK1CDK5CDK5R1GPR3ALDH1A1 | |
| SCHEMBL17463988 | 0.75 | GPR3 (0.41) | LIMK1CDK5CDK5R1GPR3ROCK1 | |
| SCHEMBL16905779 | 0.72 | GPR3 (0.38) | LIMK1CDK5CDK5R1GPR3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445482-B2 | Thieno- and furo-pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2013-05-21 | — | — | US | claimed |
| EP-3715436-B1 | COMPOSITION AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME | SAMSUNG ELECTRONICS CO LTD (KR) | 2021-12-01 | — | — | EP | disclosed |