GPR3

G-protein coupled receptor 3 · P46089 · GPR3 on Sugi Atlas →

30,323 patent compounds predicted against GPR3, 14,186 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Diphenyleneiodonium (SCHEMBL159318)	1.00	16/20
Diphenyleneiodonium (SCHEMBL219548)	1.00	16/20
SCHEMBL442684	0.48	5/20
SCHEMBL513525	0.48	5/20
Triphenylene (SCHEMBL25597)	0.47	5/20
Triphenylene (SCHEMBL311118)	0.47	5/20
SCHEMBL254534	0.50	4/20
SCHEMBL184685	0.39	4/20
SCHEMBL262425	0.39	4/20
Phenanthridine (SCHEMBL8666)	1.00	3/20
Benzonaphthyridine (SCHEMBL51197)	1.00	3/20
Phenanthridine (SCHEMBL460289)	0.95	3/20
SCHEMBL241476	0.69	3/20
SCHEMBL24582	0.62	3/20
SCHEMBL26265	0.62	3/20
SCHEMBL516091	0.54	3/20
SCHEMBL255560	0.52	3/20
SCHEMBL25148	0.50	3/20
SCHEMBL253096	0.50	3/20
SCHEMBL49870	0.47	3/20

Clinical trials — most relevant to GPR3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
A Safety and Efficacy Study of Carbidopa-levodopa in Patients With Macular Degeneration	PHASE2	WITHDRAWN
Mediterranean Diet and Inequality in Early Breast Cancer	PHASE2	RECRUITING
Dose Ranging Study of Carbidopa-levodopa	PHASE2	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
GSK618334 Repeat Dose Study	PHASE1	COMPLETED
Gastroparesis Registry 3	nan	COMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis	nan	WITHDRAWN
Metabotropic Receptors For Glutamate Type 3 In Parkinson's	nan	UNKNOWN
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients	nan	COMPLETED
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
Colonic Propionate, Appetite, and Weight Loss	nan	COMPLETED
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy)	nan	UNKNOWN
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.	nan	COMPLETED
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing	nan	COMPLETED
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis	nan	COMPLETED
Development of Therapeutic Approaches Modulating Molecular Targets Implicated on Cancer Stem Cell-related Aggressiveness	nan	UNKNOWN
Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling	nan	COMPLETED
Gut Microbiota and Modulation of Liver Damage in NAFLD	nan	COMPLETED
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity	nan	NOT_YET_RECRUITING
The Role of Autoantibodies Against G-protein Coupled Receptors in Obesity	nan	NOT_YET_RECRUITING
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein	nan	COMPLETED
Comparative Study Between Behavior Therapy and Behavior Therapy Plus Mirabegron in Sexually Active Men With OAB Symptoms	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GPR3 binder may also engage these)

Protein	Name	Similarity
Q8K1Q3	—	0.996	Q8K1Q3 →
P35413	—	0.994	P35413 →
P51651	—	0.985	P51651 →
GPR6	G-protein coupled receptor 6	0.983	landscape →
Q6YNI2	—	0.983	Q6YNI2 →
P30951	—	0.967	P30951 →
P35412	—	0.962	P35412 →
P47775	—	0.960	P47775 →
Q8NDV2	—	0.947	Q8NDV2 →
Q9QXI3	—	0.944	Q9QXI3 →
Q8BZA7	—	0.943	Q8BZA7 →
Q9BZJ8	—	0.940	Q9BZJ8 →
P60894	—	0.933	P60894 →
Q9I919	—	0.933	Q9I919 →
P60893	—	0.932	P60893 →
P60895	—	0.931	P60895 →
Q8C010	—	0.931	Q8C010 →
Q8HZP3	—	0.930	Q8HZP3 →
Q95L01	—	0.928	Q95L01 →
Q5RBG7	—	0.927	Q5RBG7 →
Q3BCU0	—	0.925	Q3BCU0 →
Q8HZP2	—	0.925	Q8HZP2 →
BDKRB1	B1 bradykinin receptor	0.924	landscape →
Q9H1Y3	—	0.924	Q9H1Y3 →
P11616	—	0.923	P11616 →
P34970	—	0.922	P34970 →
Q8HZN9	—	0.922	Q8HZN9 →
Q9NS66	—	0.922	Q9NS66 →
Q5E9H8	—	0.921	Q5E9H8 →
Q6PI62	—	0.920	Q6PI62 →