Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 3/20 | 0.67 |
| ▸ | MET | P08581 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14949670 | 1.00 | HSPB1 (0.67) | HSPB1METMAPTMEN1KMT2A | |
| SCHEMBL2859670 | 0.91 | HSPB1 (0.57) | HSPB1METMAPTMEN1KMT2A | |
| SCHEMBL2859667 | 0.91 | HSPB1 (0.57) | HSPB1METMAPTMEN1KMT2A | |
| SCHEMBL12469298 | 0.87 | HSPB1 (0.52) | HSPB1MAPTMEN1KMT2APABPC1 | |
| SCHEMBL12469297 | 0.87 | HSPB1 (0.52) | HSPB1MAPTMEN1KMT2APABPC1 | |
| SCHEMBL15301357 | 0.85 | MAPT (0.55) | HSPB1MAPTMEN1KMT2APABPC1 | |
| SCHEMBL15301358 | 0.85 | MAPT (0.55) | HSPB1MAPTMEN1KMT2APABPC1 | |
| SCHEMBL12892603 | 0.85 | HSPB1 (0.59) | HSPB1METMAPTMEN1KMT2A | |
| SCHEMBL2851303 | 0.85 | HSPB1 (0.49) | HSPB1MAPTMEN1KMT2APABPC1 | |
| SCHEMBL2851309 | 0.85 | HSPB1 (0.49) | HSPB1MAPTMEN1KMT2APABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445509-B2 | Fused heterocyclic derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-21 | — | — | US | disclosed |