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HSPB1

Heat shock protein beta-1 · P04792 · HSPB1 on Sugi Atlas →

14,972 patent compounds predicted against HSPB1, 9,276 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL282823 SCHEMBL282823 0.66 8/20
SCHEMBL198095 SCHEMBL198095 0.55 6/20
SCHEMBL57112 SCHEMBL57112 0.54 6/20
SCHEMBL1137132 SCHEMBL1137132 0.51 6/20
SCHEMBL680402 SCHEMBL680402 0.50 6/20
SCHEMBL693017 SCHEMBL693017 0.54 5/20
SCHEMBL199649 SCHEMBL199649 0.54 5/20
SCHEMBL1136784 SCHEMBL1136784 0.54 5/20
SCHEMBL197935 SCHEMBL197935 0.53 5/20
SCHEMBL740006 SCHEMBL740006 0.53 5/20
SCHEMBL1136110 SCHEMBL1136110 0.51 5/20
SCHEMBL1135919 SCHEMBL1135919 0.50 5/20
SCHEMBL1136078 SCHEMBL1136078 0.50 5/20
SCHEMBL307534 SCHEMBL307534 0.47 5/20
SCHEMBL680857 SCHEMBL680857 0.46 5/20
SCHEMBL680304 SCHEMBL680304 0.45 5/20
SCHEMBL310286 SCHEMBL310286 0.44 5/20
SCHEMBL686890 SCHEMBL686890 0.44 5/20
SCHEMBL1041139 SCHEMBL1041139 0.44 5/20
SCHEMBL364168 SCHEMBL364168 1.00 4/20

Clinical trials — most relevant to HSPB1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Spironolactone on Acute Kidney Injury in Critically Ill Patients PHASE3UNKNOWN
OGX-427 in Castration Resistant Prostate Cancer Patients PHASE2COMPLETED
17AAG to Treat Kidney Tumors in Von Hippel-Lindau Disease PHASE2COMPLETED
Targeting the Tumor Microenvironment in R/M SCCHN PHASE1/PHASE2UNKNOWN
Gemcitabine, Docetaxel, and Hydroxychloroquine in Treating Participants With Recurrent or Refractory Osteosarcoma PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Targeting Endoplasmic Reticulum Stress in Human Hypertension PHASE1/PHASE2RECRUITING
Colchicine for Amyotrophic Lateral Sclerosis PHASE2COMPLETED
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors PHASE1COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors PHASE1COMPLETED
SNX-5422 to Treat Solid Tumor Cancers and Lymphomas PHASE1COMPLETED
HS-201, an HSP90 Inhibitor-linked Verteporfin for Detection of Solid Malignancies PHASE1WITHDRAWN
Once or Twice Daily Administration of BIIB021 to Subjects With Advanced Solid Tumors PHASE1COMPLETED
Safety and Pharmacology Study of SNX-5422 in Subjects With Resistant Lung Adenocarcinoma PHASE1COMPLETED
Safety Study of IPI-504 in Patients With Relapsed and Relapsed Refractory Multiple Myeloma PHASE1COMPLETED
LncRNA Nicotinamide Nucleotide Transhydrogenase-Antisense RNA1 NNT-AS1 in CRC nanCOMPLETED
Exercise on Expression of Heat Shock Protein 70 in Arterial Risk nanCOMPLETED
Perfusion-Induced Hyperthermia for Metastatic Carcinoma nanCOMPLETED
Trial of Nonsurgical Treatment of Intermittent Claudication Due to Femoro-popliteal Disease nanCOMPLETED
Acute Passive Heating in Healthy Older Adults nanCOMPLETED
The Role of HSP90 in Peripheral Vascular Lesions of Diabetic Atherosclerosis nanCOMPLETED
Chronic Heat Therapy for Improving Vascular Health nanCOMPLETED
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) nanRECRUITING
Cardioprotective Benefit of Passive Heat Therapy in Higher-Level Spinal Cord Injury: Safety and Proof of Concept nanUNKNOWN
Relationship Between Polymorphism of Heat Shock Protein 70 Gene and Hepatocellular Carcinoma nanCOMPLETED
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases. nanNOT_YET_RECRUITING
Chronic Passive Heating in Healthy Older Adults nanCOMPLETED
Oral Glutamine in Cardiopulmonary Bypass nanCOMPLETED
Establishment of Human Cellular Disease Models for Wilson Disease nanCOMPLETED
BASE HSP110 : A New Therapeutic Target and a New Marker for Prognosis of Type MSI Colorectal Cancer nanUNKNOWN
Muscle Wasting in Cancer (MWIC) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a HSPB1 binder may also engage these)

ProteinNameSimilarity
P14602 — 1.000 P14602 →
Q3T149 — 1.000 Q3T149 →
P42930 — 1.000 P42930 →
Q5S1U1 — 1.000 Q5S1U1 →
Q00649 — 0.998 Q00649 →
P42929 — 0.996 P42929 →
P15991 — 0.991 P15991 →
O13224 — 0.989 O13224 →
Q6SJQ8 — 0.986 Q6SJQ8 →
P02512 — 0.984 P02512 →
Q5EBG6 — 0.984 Q5EBG6 →
P82147 — 0.983 P82147 →
P97541 — 0.983 P97541 →
P02500 — 0.983 P02500 →
Q05713 — 0.981 Q05713 →
Q9JK92 — 0.981 Q9JK92 →
Q05557 — 0.980 Q05557 →
Q8MJ36 — 0.978 Q8MJ36 →
Q5RAB0 — 0.978 Q5RAB0 →
Q9UJY1 — 0.977 Q9UJY1 →
Q148F8 — 0.976 Q148F8 →
Q5EAC9 — 0.975 Q5EAC9 →
O93591 — 0.974 O93591 →
P02509 — 0.974 P02509 →
P24622 — 0.974 P24622 →
P02518 — 0.972 P02518 →
Q91312 — 0.972 Q91312 →
P24623 — 0.972 P24623 →
Q9EPX0 — 0.971 Q9EPX0 →
P02508 — 0.971 P02508 →