Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 7/20 | 0.60 |
| ▸ | TPO | P07202 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | WEE1 | P30291 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14947165 | 0.89 | MPO (0.59) | MPOTPOGAAMAPK1GRIN1 | |
| SCHEMBL14947171 | 0.89 | MPO (0.76) | MPOTPOGAAMAPK1GRIN1 | |
| SCHEMBL14936194 | 0.87 | MPO (0.60) | MPOTPOGAAGRIN1GRIN2B | |
| SCHEMBL14936542 | 0.87 | MPO (0.81) | MPOTPOGAAMAPK1GRIN1 | |
| SCHEMBL14947169 | 0.83 | MPO (0.81) | MPOTPOGAAMAPK1GRIN1 | |
| SCHEMBL14947166 | 0.82 | MPO (0.59) | MPOTPOGRIN1GRIN2BMEN1 | |
| SCHEMBL14936590 | 0.81 | MPO (0.81) | MPOTPOGAAMAPK1GRIN1 | |
| SCHEMBL14947160 | 0.79 | MPO (0.81) | MPOTPOGAAMAPK1GRIN1 | |
| SCHEMBL14947168 | 0.77 | MPO (0.58) | MPOTPOGAAMAPK1GRIN1 | |
| SCHEMBL14936647 | 0.75 | MPO (1.00) | MPOTPOGAAMAPK1GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068875-A1 | 2-THIOPYRIMIDINONES | PFIZER INC. (US) | 2013-05-16 | — | — | WO | disclosed |