Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.58 |
| ▸ | SMO | Q99835 | 4/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | STAT6 | P42226 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3623664 | 0.91 | GPR119 (0.58) | GPR119KCNH2KDM4ENPC1ALDH1A1 | |
| SCHEMBL14958955 | 0.79 | GPR119 (0.67) | GPR119KCNH2SMOKDM1A | |
| SCHEMBL3624959 | 0.79 | GPR119 (0.61) | GPR119KCNH2KDM1A | |
| SCHEMBL14958961 | 0.78 | GPR119 (0.60) | GPR119KCNH2SMO | |
| SCHEMBL14958958 | 0.75 | GPR119 (0.69) | GPR119KCNH2KDM1A | |
| SCHEMBL3625685 | 0.74 | AR (0.53) | GPR119KCNH2 | |
| SCHEMBL3610688 | 0.74 | GPR119 (0.83) | GPR119KCNH2KDM1AKDM4ENPC1 | |
| SCHEMBL3611177 | 0.74 | GPR119 (1.00) | GPR119KCNH2KDM1A | |
| SCHEMBL14958956 | 0.74 | GPR119 (0.61) | GPR119KCNH2KDM1A | |
| SCHEMBL12874467 | 0.73 | GPR119 (0.61) | GPR119KCNH2SMOKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445499-B2 | Bipiperidinyl compounds, compositions, containing such compounds and methods of treatment | MERCK SHARP & DOHME CORP. (US) | 2013-05-21 | — | — | US | disclosed |