Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMEL1 | Q495T6 | 11/20 | 0.67 |
| ▸ | MME | P08473 | 11/20 | 0.56 |
| ▸ | ACE | P12821 | 6/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8579481 | 1.00 | MMEL1 (0.67) | MMEL1MMEACE | |
| SCHEMBL2877479 | 0.92 | MMEL1 (0.72) | MMEL1MMEACE | |
| SCHEMBL2877483 | 0.92 | MMEL1 (0.72) | MMEL1MMEACE | |
| SCHEMBL8552535 | 0.86 | MMEL1 (0.67) | MMEL1MMEACE | |
| SCHEMBL1912538 | 0.85 | MMEL1 (0.79) | MMEL1MMEACE | |
| SCHEMBL12975326 | 0.85 | MMEL1 (0.73) | MMEL1MMEACE | |
| SCHEMBL1912542 | 0.85 | MMEL1 (0.79) | MMEL1MMEACE | |
| SCHEMBL1912639 | 0.85 | MMEL1 (0.78) | MMEL1MMEACE | |
| SCHEMBL1912636 | 0.85 | MMEL1 (0.78) | MMEL1MMEACE | |
| SCHEMBL10198457 | 0.84 | MMEL1 (0.66) | MMEL1MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594557-B1 | Substituted aminopropionic derivatives as neprilysin inhibitors | NOVARTIS AG (CH) | 2016-08-10 | — | — | EP | disclosed |
| EP-2594556-A1 | Substituted aminopropionic derivatives as neprilysin inhibitors | Novartis AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| EP-2594557-A1 | Substituted aminopropionic derivatives as neprilysin inhibitors | Novartis AG (CH) | 2013-05-22 | — | — | EP | disclosed |