Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMEL1 | Q495T6 | 13/20 | 0.59 |
| ▸ | MME | P08473 | 9/20 | 0.55 |
| ▸ | ACE | P12821 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14959424 | 0.91 | MMEL1 (0.60) | MMEL1MME | |
| SCHEMBL14870603 | 0.90 | MMEL1 (0.54) | MMEL1MMEACE | |
| SCHEMBL2878303 | 0.85 | MMEL1 (0.60) | MMEL1MMEACE | |
| SCHEMBL2876189 | 0.85 | MMEL1 (0.60) | MMEL1MMEACE | |
| SCHEMBL2870528 | 0.83 | MMEL1 (0.68) | MMEL1MMEACE | |
| SCHEMBL2870535 | 0.83 | MMEL1 (0.68) | MMEL1MMEACE | |
| SCHEMBL10197740 | 0.81 | MMEL1 (0.48) | MMEL1MME | |
| SCHEMBL2873434 | 0.76 | MMEL1 (0.80) | MMEL1MMEACE | |
| SCHEMBL2872795 | 0.76 | MMEL1 (0.61) | MMEL1MMEACE | |
| SCHEMBL2873431 | 0.76 | MMEL1 (0.80) | MMEL1MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435409-B1 | SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS | NOVARTIS AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| EP-2594556-A1 | Substituted aminopropionic derivatives as neprilysin inhibitors | Novartis AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| EP-2594557-A1 | Substituted aminopropionic derivatives as neprilysin inhibitors | Novartis AG (CH) | 2013-05-22 | — | — | EP | disclosed |