Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 2/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.41 |
| ▸ | ITGAL | P20701 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18552977 | 0.92 | ITGB2 (0.41) | ITGB2ICAM1ITGALCYP3A4SLC7A5 | |
| SCHEMBL16802380 | 0.92 | ITGB2 (0.41) | ITGB2ICAM1ITGALCYP3A4SLC7A5 | |
| SCHEMBL18159672 | 0.90 | ITGB2 (0.42) | ITGB2ICAM1ITGALCYP3A4SLC7A5 | |
| SCHEMBL18159671 | 0.90 | ITGB2 (0.42) | ITGB2ICAM1ITGALCYP3A4SLC7A5 | |
| SCHEMBL18375958 | 0.86 | ITGB2 (0.41) | ITGB2ICAM1ITGALCYP3A4SLC7A5 | |
| SCHEMBL18786594 | 0.86 | ITGB2 (0.41) | ITGB2ICAM1ITGALCYP3A4SLC7A5 | |
| SCHEMBL17570989 | 0.84 | ITGB2 (0.39) | ITGB2ICAM1ITGALCYP3A4SLC7A5 | |
| SCHEMBL20661666 | 0.83 | ITGB2 (0.41) | ITGB2ICAM1ITGALCYP3A4SLC7A5 | |
| SCHEMBL17750695 | 0.82 | HRH3 (0.40) | ITGB2ICAM1ITGALCYP3A4SLC7A5 | |
| SCHEMBL15691407 | 0.82 | HRH3 (0.40) | ITGB2ICAM1ITGALCYP3A4SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9080171-B2 | Reduced size self-delivering RNAi compounds | RXi Parmaceuticals Corporation (US) | 2015-07-14 | — | — | US | disclosed |
| US-20130131141-A1 | REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS | PHIO PHARMACEUTICALS CORP. | 2013-05-23 | — | — | US | disclosed |
| US-20130131142-A1 | RNA INTERFERENCE IN OCULAR INDICATIONS | PHIO PHARMACEUTICALS CORP. | 2013-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131142-A1 | RNA INTERFERENCE IN OCULAR INDICATIONS | RXRA, RXRB, RXRG | ITGB2 846/4885ICAM1 3080/4885ITGAL 1284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.