Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.36 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14442675 | 1.00 | LMNA (0.41) | LMNAKMT2ACYP1A2CYP2C19EGFR | |
| Trifluoroacetic Acid SCHEMBL5631666 | 0.95 | KMT2A (0.37) | LMNAKMT2AEGFRNPC1THRB | |
| Trifluoroacetic Acid SCHEMBL5631683 | 0.95 | KMT2A (0.37) | LMNAKMT2AEGFRNPC1THRB | |
| SCHEMBL14462406 | 0.89 | LMNA (0.41) | LMNAKMT2ACYP1A2CYP2C19EGFR | |
| SCHEMBL4986029 | 0.89 | LMNA (0.48) | LMNAKMT2AEGFRTHRBPIK3CD | |
| SCHEMBL4985998 | 0.89 | LMNA (0.48) | LMNAKMT2AEGFRTHRBPIK3CD | |
| SCHEMBL5631667 | 0.88 | PIK3CD (0.38) | LMNAKMT2AEGFRNPC1THRB | |
| SCHEMBL14964167 | 0.85 | IDO1 (0.50) | — | |
| SCHEMBL5631978 | 0.84 | PTGDR2 (0.40) | KMT2ACYP1A2CYP2C19NPC1THRB | |
| SCHEMBL5631989 | 0.84 | PTGDR2 (0.40) | KMT2ACYP1A2CYP2C19NPC1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |
| EP-1971583-B1 | N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | INCYTE CORP (US) | 2015-03-25 | — | — | EP | disclosed |