Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.68 |
| ▸ | CDK2 | P24941 | 15/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 13/20 | 0.58 |
| ▸ | CCNA1 | P78396 | 12/20 | 0.58 |
| ▸ | CDK9 | P50750 | 8/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.58 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.58 |
| ▸ | GSK3A | P49840 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.58 |
| ▸ | CCNE2 | O96020 | 8/20 | 0.58 |
| ▸ | CDK1 | P06493 | 3/20 | 0.57 |
| ▸ | CCNK | O75909 | 2/20 | 0.57 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.57 |
| ▸ | CDK4 | P11802 | 1/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.57 |
| ▸ | CCND1 | P24385 | 1/20 | 0.57 |
| ▸ | CDK7 | P50613 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14977880 | 0.89 | CCNE2 (0.60) | DYRK1ACDK2CCNA2CCNA1CDK5 | |
| SCHEMBL3507625 | 0.88 | DYRK1A (0.68) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL3510112 | 0.86 | TDP1 (0.62) | DYRK1ACDK2CDK5CDK1CCNB1 | |
| SCHEMBL13907136 | 0.86 | DYRK1A (0.75) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL3960323 | 0.84 | DYRK1A (0.63) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL13030951 | 0.83 | DYRK1A (0.92) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL14964232 | 0.82 | DYRK1A (0.75) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL13030940 | 0.81 | DYRK1A (1.00) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL14977879 | 0.81 | DYRK1A (0.79) | DYRK1ACDK2CCNA2CCNA1CDK9 | |
| SCHEMBL14964243 | 0.81 | DYRK1A (0.79) | DYRK1ACDK2CCNA2CCNA1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450315-B2 | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450342-B2 | Perharidines as CDK inhibitors | CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-05-28 | — | — | US | disclosed |