Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 16/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 16/20 | 0.60 |
| ▸ | CDK2 | P24941 | 16/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 12/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 12/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CCNK | O75909 | 1/20 | 0.54 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 2/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3510112 | 0.93 | TDP1 (0.62) | CDK2KDM4ENPC1MAPTTDP1 | |
| SCHEMBL14964174 | 0.89 | DYRK1A (0.68) | CCNE2CCNE1CDK2CCNA2CCNA1 | |
| SCHEMBL14964187 | 0.87 | CDK1 (0.59) | CCNE2CCNE1CDK2CCNA2CCNA1 | |
| SCHEMBL14977882 | 0.82 | DYRK1A (0.58) | CCNE2CCNE1CDK2CCNA2CCNA1 | |
| SCHEMBL14964207 | 0.81 | CCNE2 (0.54) | CCNE2CCNE1CDK2CCNA2CCNA1 | |
| SCHEMBL14964177 | 0.81 | CCNE2 (0.54) | CCNE2CCNE1CDK2CCNA2CCNA1 | |
| SCHEMBL14964188 | 0.81 | CCNE2 (0.54) | CCNE2CCNE1CDK2CCNA2CCNA1 | |
| Hydrochloric Acid SCHEMBL14964329 | 0.81 | CCNE2 (0.54) | CCNE2CCNE1CDK2CCNA2CCNA1 | |
| Hydrochloric Acid SCHEMBL14964171 | 0.81 | CCNE2 (0.54) | CCNE2CCNE1CDK2CCNA2CCNA1 | |
| Hydrochloric Acid SCHEMBL14964170 | 0.81 | CCNE2 (0.54) | CCNE2CCNE1CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450342-B2 | Perharidines as CDK inhibitors | CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-05-28 | — | — | US | disclosed |
| US-8450342-B2 | Perharidines as CDK inhibitors | CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-05-28 | — | — | US | disclosed |