SCHEMBL14964213

SCHEMBL14964213

ONC(=Nc1ccc(F)c(Cl)c1)c1nonc1Cn1nnc(CN2CCOCC2)n1

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 20/20 0.50
TDO2 P48775 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4986046 0.89 IDO1 (0.60) IDO1TDO2
SCHEMBL5630657 0.87 IDO1 (0.39) IDO1TDO2
SCHEMBL14964212 0.85 LMNA (0.41)
SCHEMBL14442662 0.85 LMNA (0.41)
SCHEMBL14964167 0.84 IDO1 (0.50) IDO1TDO2
SCHEMBL5631095 0.84 IDO1 (0.52) IDO1TDO2
SCHEMBL5630429 0.83 IDO1 (0.62) IDO1TDO2
SCHEMBL4984483 0.83 IDO1 (0.57) IDO1TDO2
SCHEMBL5630142 0.83 IDO1 (0.52) IDO1TDO2
SCHEMBL5631485 0.82 IDO1 (0.59) IDO1TDO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8450351-B2 N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase INCYTE CORPORATION (US) 2013-05-28 US claimed