Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 20/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16435125 | 0.90 | IDO1 (0.44) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL1825528 | 0.86 | IDO1 (0.61) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL21377867 | 0.84 | IDO1 (0.63) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL1821756 | 0.84 | IDO1 (0.55) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL14964302 | 0.83 | IDO1 (0.45) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL15100348 | 0.82 | IDO1 (0.48) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL14964366 | 0.82 | IDO1 (0.44) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL14964191 | 0.81 | IDO1 (0.40) | IDO1 | |
| SCHEMBL14964327 | 0.81 | IDO1 (0.42) | IDO1 | |
| SCHEMBL14964252 | 0.79 | IDO1 (0.45) | IDO1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |