Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 17/20 | 0.45 |
| ▸ | TDO2 | P48775 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14461960 | 0.90 | IDO1 (0.44) | IDO1TDO2CYP3A4CYP2C9IDO2 | |
| SCHEMBL1824292 | 0.86 | IDO1 (0.54) | IDO1TDO2CYP3A4CYP2C9IDO2 | |
| SCHEMBL14964252 | 0.85 | IDO1 (0.45) | IDO1CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL14964253 | 0.83 | IDO1 (0.47) | IDO1TDO2CYP3A4CYP2C9IDO2 | |
| SCHEMBL15100473 | 0.83 | IDO1 (0.46) | IDO1TDO2CYP3A4CYP2C9IDO2 | |
| SCHEMBL4971385 | 0.80 | ALDH1A1 (0.38) | IDO1TDO2CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL14964328 | 0.80 | IDO1 (0.37) | IDO1TDO2CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL14964354 | 0.79 | ALDH1A1 (0.39) | IDO1TDO2CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL4984827 | 0.79 | CA2 (0.44) | IDO1CYP3A4CYP2C9 | |
| SCHEMBL14964338 | 0.79 | IDO1 (0.35) | IDO1TDO2CYP3A4CYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8951536-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2015-02-10 | — | — | US | claimed |
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | claimed |