Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.82 |
| ▸ | CDK2 | P24941 | 10/20 | 0.70 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.70 |
| ▸ | CCNK | O75909 | 7/20 | 0.70 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.70 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.70 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.70 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.70 |
| ▸ | CDK1 | P06493 | 10/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.61 |
| ▸ | CDK9 | P50750 | 5/20 | 0.61 |
| ▸ | CDK7 | P50613 | 5/20 | 0.61 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.61 |
| ▸ | CDK4 | P11802 | 3/20 | 0.61 |
| ▸ | CCND1 | P24385 | 3/20 | 0.61 |
| ▸ | CCNH | P51946 | 3/20 | 0.61 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.61 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.61 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.61 |
| ▸ | CLK2 | P49760 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964249 | 1.00 | DYRK1A (0.82) | DYRK1ACDK2CCNE1CCNKCDK12 | |
| SCHEMBL13030937 | 0.94 | DYRK1A (0.79) | DYRK1ACDK2CCNE1CCNKCDK12 | |
| SCHEMBL13030936 | 0.94 | DYRK1A (0.79) | DYRK1ACDK2CCNE1CCNKCDK12 | |
| SCHEMBL3508659 | 0.94 | DYRK1A (0.79) | DYRK1ACDK2CCNE1CCNKCDK12 | |
| SCHEMBL13030940 | 0.91 | DYRK1A (1.00) | DYRK1ACDK2CCNE1CCNKCDK12 | |
| SCHEMBL14964582 | 0.91 | DYRK1A (1.00) | DYRK1ACDK2CCNE1CCNKCDK12 | |
| SCHEMBL13030939 | 0.91 | DYRK1A (1.00) | DYRK1ACDK2CCNE1CCNKCDK12 | |
| SCHEMBL13030951 | 0.86 | DYRK1A (0.92) | DYRK1ACDK2CCNE1CCNKCDK12 | |
| SCHEMBL17628573 | 0.83 | CDK2 (1.00) | DYRK1ACDK2CCNE1CCNKCDK12 | |
| SCHEMBL14977882 | 0.83 | DYRK1A (0.58) | DYRK1ACDK2CCNE1CCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450342-B2 | Perharidines as CDK inhibitors | CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-05-28 | — | — | US | disclosed |
| US-8450342-B2 | Perharidines as CDK inhibitors | CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-05-28 | — | — | US | disclosed |
| US-8450342-B2 | Perharidines as CDK inhibitors | CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-05-28 | — | — | US | disclosed |