Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 5/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3739391 | 0.90 | CXCR3 (0.75) | CXCR3KCNH2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL115433 | 0.90 | MAPT (0.47) | CXCR3KCNH2GRIN2BMAPTALDH1A1 | |
| SCHEMBL3734848 | 0.83 | CXCR3 (0.74) | CXCR3KCNH2ALDH1A1LMNATP53 | |
| SCHEMBL114594 | 0.82 | CXCR3 (0.44) | CXCR3KCNH2GRIN2BMAPTALDH1A1 | |
| SCHEMBL3735612 | 0.82 | GRIN2B (0.42) | CXCR3KCNH2GRIN2BMAPTALDH1A1 | |
| SCHEMBL3731490 | 0.81 | CXCR3 (0.81) | CXCR3KCNH2MAPTALDH1A1LMNA | |
| SCHEMBL3728373 | 0.81 | CXCR3 (0.74) | CXCR3KCNH2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL17854891 | 0.81 | CXCR3 (0.60) | CXCR3KCNH2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3727343 | 0.81 | CXCR3 (0.74) | CXCR3KCNH2MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3730804 | 0.81 | GRIN2B (0.43) | CXCR3KCNH2GRIN2BMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450317-B2 | CXCR3 receptor antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-28 | — | — | US | claimed |