Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 13/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.67 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.67 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29966428 | 0.87 | SLC6A2 (0.63) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL15654221 | 0.87 | SLC6A2 (0.63) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL20473750 | 0.87 | SLC6A2 (0.63) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL159543 | 0.87 | SLC6A2 (0.63) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL5155786 | 0.85 | SLC6A2 (0.66) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL4201508 | 0.85 | SLC6A2 (0.68) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL7038411 | 0.85 | SLC6A2 (0.68) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL7109307 | 0.85 | SLC6A2 (0.68) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| Isalmadol SCHEMBL5534029 | 0.83 | SLC6A2 (0.66) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| Isalmadol SCHEMBL6437705 | 0.83 | SLC6A2 (0.66) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780000-A1 | TAMPER-RESISTANT ORAL PHARMACEUTICAL DOSAGE FORM COMPRISING A PHARMACOLOGICALLY ACTIVE INGREDIENT, AN OPIOID ANTAGONIST AND/OR AVERSIVE AGENT, POLYALKYLENE OXIDE AND ANIONIC POLYMER | Grünenthal GmbH (DE) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072395-A1 | TAMPER-RESISTANT ORAL PHARMACEUTICAL DOSAGE FORM COMPRISING A PHARMACOLOGICALLY ACTIVE INGREDIENT, AN OPIOID ANTAGONIST AND/OR AVERSIVE AGENT, POLYALKYLENE OXIDE AND ANIONIC POLYMER | Grünenthal GmbH (DE) | 2013-05-23 | — | — | WO | disclosed |