⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14968808 | 0.89 | SMN1; SMN2 (0.50) | — | |
| SCHEMBL14964873 | 0.86 | KDM4E (0.54) | — | |
| SCHEMBL14965940 | 0.81 | SMN1; SMN2 (0.50) | — | |
| SCHEMBL14965111 | 0.80 | — | — | |
| SCHEMBL14964872 | 0.78 | SMN1; SMN2 (0.55) | — | |
| SCHEMBL14965098 | 0.77 | SMN1; SMN2 (0.46) | — | |
| SCHEMBL14965138 | 0.77 | SMN1; SMN2 (0.46) | — | |
| SCHEMBL14964930 | 0.76 | SMN1; SMN2 (0.54) | — | |
| SCHEMBL14965005 | 0.76 | LMNA (0.64) | — | |
| SCHEMBL14965414 | 0.76 | SMN1; SMN2 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |