Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964960 | 0.95 | ADRB2 (0.35) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL16293556 | 0.82 | KMT2A (0.32) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL14964986 | 0.82 | ADRB2 (0.32) | ADRB2ADRB1ADRB3 | |
| SCHEMBL14965724 | 0.80 | ADRB2 (0.32) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL14965113 | 0.78 | — | — | |
| SCHEMBL14968875 | 0.69 | MAPT (0.49) | KMT2AMEN1MAPTHTTSMN1; SMN2 | |
| SCHEMBL14965024 | 0.65 | POLB (0.47) | ADRB3KMT2AHTT | |
| SCHEMBL14965249 | 0.63 | KMT2A (0.49) | ADRB3KMT2AHTT | |
| SCHEMBL27978693 | 0.59 | MEN1 (0.45) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL27978754 | 0.59 | STAT3 (0.43) | ADRB2ADRB1ADRB3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |