Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965500 | 0.90 | POLB (0.58) | POLBHTTKMT2A | |
| SCHEMBL16293295 | 0.90 | POLB (0.58) | POLBHTTKMT2A | |
| SCHEMBL16294075 | 0.88 | POLB (0.55) | POLBHTTKMT2A | |
| SCHEMBL14965008 | 0.85 | POLB (0.64) | POLBHTTKMT2A | |
| SCHEMBL16293181 | 0.85 | LMNA (0.57) | POLBHTTKMT2A | |
| SCHEMBL14965326 | 0.84 | POLB (0.51) | POLBHTTKMT2A | |
| SCHEMBL16294015 | 0.84 | POLB (0.66) | POLBHTTKMT2A | |
| SCHEMBL14965145 | 0.83 | POLB (0.61) | POLBHTTKMT2A | |
| SCHEMBL16293150 | 0.80 | POLB (0.61) | POLBHTTKMT2A | |
| SCHEMBL14965364 | 0.79 | ADRB3 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780343-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072694-A1 | THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2013-05-23 | — | — | WO | disclosed |