Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.76 |
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | CDK2 | P24941 | 1/20 | 0.65 |
| ▸ | FLT4 | P35916 | 1/20 | 0.65 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.65 |
| ▸ | GSK3A | P49840 | 1/20 | 0.65 |
| ▸ | GSK3B | P49841 | 1/20 | 0.65 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.65 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.65 |
| ▸ | STK3 | Q13188 | 1/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.65 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.65 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.65 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18780302 | 1.00 | CHEK1 (0.76) | CHEK1AURKACDK2FLT4FLT3 | |
| SCHEMBL18780355 | 0.87 | CHEK1 (0.76) | CHEK1AURKACDK2FLT4FLT3 | |
| SCHEMBL2593415 | 0.86 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL16206653 | 0.84 | CHEK1 (0.88) | CHEK1FLT4FLT3RPS6KA3PRKD2 | |
| SCHEMBL16206635 | 0.84 | CHEK1 (0.88) | CHEK1FLT4FLT3RPS6KA3PRKD2 | |
| SCHEMBL14965385 | 0.84 | CHEK1 (0.74) | CHEK1AURKACDK2FLT4FLT3 | |
| Hydrochloric Acid SCHEMBL17684931 | 0.84 | CHEK1 (0.86) | CHEK1FLT4FLT3RPS6KA3PRKD2 | |
| SCHEMBL2589904 | 0.84 | CHEK1 (1.00) | CHEK1 | |
| Hydrochloric Acid SCHEMBL17684925 | 0.84 | CHEK1 (0.86) | CHEK1FLT4FLT3RPS6KA3PRKD2 | |
| Hydrochloric Acid SCHEMBL16195313 | 0.83 | CHEK1 (0.73) | CHEK1AURKACDK2FLT4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9630931-B2 | Pharmaceutically active pyrazine derivatives | SENTINEL ONCOLOGY LIMITED (GB) | 2017-04-25 | — | — | US | disclosed |