Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | USP5 | P45974 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965418 | 0.91 | TP53 (0.35) | TP53NPY5RMEN1KMT2AUSP5 | |
| SCHEMBL14965556 | 0.84 | TP53 (0.34) | TP53NPY5RMEN1KMT2ASYK | |
| SCHEMBL14965174 | 0.83 | TP53 (0.33) | TP53NPY5R | |
| SCHEMBL362899 | 0.80 | TLR8 (0.40) | TP53NPY5RMEN1KMT2ASYK | |
| SCHEMBL14965192 | 0.78 | — | — | |
| SCHEMBL14965937 | 0.78 | — | — | |
| SCHEMBL14965704 | 0.76 | HTR2C (0.34) | — | |
| SCHEMBL364963 | 0.71 | GPBAR1 (0.32) | — | |
| SCHEMBL14936672 | 0.71 | GPBAR1 (0.44) | NPY5RMEN1KMT2ASYK | |
| SCHEMBL14936678 | 0.71 | GPBAR1 (0.44) | NPY5RMEN1KMT2ASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780330-A1 | 1-PYRIDAZINYL-HYDROXYIMINO- 3- PHENYL- PROPANES AS GPBAR1 AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072265-A1 | 1-PYRIDAZINYL-HYDROXYIMINO- 3- PHENYL- PROPANES AS GPBAR1 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-23 | — | — | WO | disclosed |