Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965404 | 0.83 | TP53 (0.33) | TP53NPY5R | |
| SCHEMBL14965418 | 0.81 | TP53 (0.35) | TP53TSHREGFRNPY5R | |
| SCHEMBL364225 | 0.81 | TLR8 (0.39) | TP53NPY5R | |
| SCHEMBL363415 | 0.71 | TLR8 (0.42) | TP53 | |
| SCHEMBL364904 | 0.71 | TLR8 (0.38) | TP53 | |
| SCHEMBL14936678 | 0.70 | GPBAR1 (0.44) | TSHRNPY5R | |
| SCHEMBL14936674 | 0.70 | GPBAR1 (0.44) | TSHRNPY5R | |
| SCHEMBL14936672 | 0.70 | GPBAR1 (0.44) | TSHRNPY5R | |
| SCHEMBL14936676 | 0.70 | GPBAR1 (0.44) | TSHRNPY5R | |
| SCHEMBL14965556 | 0.69 | TP53 (0.34) | TP53NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780330-A1 | 1-PYRIDAZINYL-HYDROXYIMINO- 3- PHENYL- PROPANES AS GPBAR1 AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072265-A1 | 1-PYRIDAZINYL-HYDROXYIMINO- 3- PHENYL- PROPANES AS GPBAR1 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-23 | — | — | WO | disclosed |