Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 3/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.52 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14965885 | 0.87 | NPC1 (0.55) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL15391649 | 0.81 | ABL1 (0.61) | MEN1KMT2AMAPTABL1 | |
| SCHEMBL28105100 | 0.81 | LMNA (0.66) | SMN1; SMN2MAPTABL1TRPV1LMNA | |
| SCHEMBL14966135 | 0.80 | NPC1 (0.57) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL29206909 | 0.80 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL14965803 | 0.78 | MEN1 (0.64) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL14965268 | 0.78 | MEN1 (0.64) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL13279297 | 0.78 | PDE4B (0.54) | SMN1; SMN2MAPTEPHX2LMNATP53 | |
| SCHEMBL2721728 | 0.78 | CA12 (0.59) | MEN1KMT2ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL15932597 | 0.77 | MAPT (0.58) | MEN1KMT2ASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072903-A1 | NITROIMIDAZOXADIAZOCINE COMPOUNDS | ITHEMBA PHARMACEUTICALS (PROPRIETARY) LIMITED (ZA) | 2013-05-23 | — | — | WO | disclosed |