Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 6/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.36 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966264 | 0.96 | KDM4E (0.44) | KDM4EMEN1RGS12NPC1USP2 | |
| SCHEMBL14965908 | 0.85 | AURKA (0.39) | KDM4EMEN1RGS12NPC1USP2 | |
| SCHEMBL14965951 | 0.84 | PI4KB (0.32) | KDM4EMEN1RGS12NPC1USP2 | |
| SCHEMBL14965954 | 0.84 | PI4KB (0.32) | KDM4EMEN1RGS12NPC1USP2 | |
| SCHEMBL14966310 | 0.80 | SIRT2 (0.40) | MEN1NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL30778591 | 0.77 | KDM4E (0.43) | KDM4EMEN1RGS12NPC1USP2 | |
| SCHEMBL14966507 | 0.76 | SIRT2 (0.44) | MEN1NPC1HTTRAB9AKMT2A | |
| SCHEMBL29703260 | 0.76 | GAA (0.47) | MEN1NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL24861043 | 0.75 | CRBN (0.57) | — | |
| SCHEMBL5195277 | 0.74 | PDE1B (0.50) | PDE9APDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013072825-A1 | PHTALAZINONE DERIVATIVES AS MPEGS -1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-05-23 | — | — | WO | disclosed |