Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966412 | 0.89 | GPR119 (0.40) | GPR119KCNH2CYP3A4 | |
| SCHEMBL14966716 | 0.88 | GPR119 (0.36) | GPR119KCNH2CYP3A4NR1H2NR1H3 | |
| SCHEMBL14966494 | 0.81 | GPR119 (0.38) | GPR119KCNH2CYP3A4 | |
| SCHEMBL14965995 | 0.80 | GPR119 (0.44) | GPR119KCNH2CYP3A4NR1H2NR1H3 | |
| SCHEMBL925798 | 0.71 | GPR119 (0.65) | GPR119KCNH2 | |
| SCHEMBL14966410 | 0.69 | GPR119 (0.40) | GPR119KCNH2 | |
| SCHEMBL14966714 | 0.68 | GPR119 (0.35) | GPR119NR1H2NR1H3 | |
| SCHEMBL2598425 | 0.68 | GPR119 (0.42) | GPR119KCNH2 | |
| SCHEMBL2599393 | 0.68 | GPR119 (0.43) | GPR119KCNH2CYP3A4 | |
| SCHEMBL12186171 | 0.68 | GPR119 (0.43) | GPR119KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013074641-A1 | PIPERIDINYL- SUBSTITUTED CYCLIC UREAS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2013-05-23 | — | — | WO | disclosed |