Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966383 | 1.00 | CYP1A2 (0.31) | CYP1A2CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL14966233 | 0.79 | — | — | |
| SCHEMBL14966384 | 0.79 | — | — | |
| SCHEMBL23866610 | 0.79 | CYP1A2 (0.42) | CYP1A2 | |
| SCHEMBL21661348 | 0.79 | CYP1A2 (0.42) | CYP1A2 | |
| SCHEMBL21661359 | 0.77 | KDM4E (0.38) | CYP3A4 | |
| SCHEMBL21661207 | 0.69 | CYP2D6 (0.38) | CYP1A2CYP2C19 | |
| SCHEMBL23866602 | 0.69 | CYP2D6 (0.38) | CYP1A2CYP2C19 | |
| SCHEMBL23866605 | 0.69 | CYP2D6 (0.38) | CYP1A2CYP2C19 | |
| SCHEMBL29542772 | 0.68 | KDM4E (0.44) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-B9 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2018-04-18 | — | — | EP | disclosed |
| EP-2780039-B1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2017-11-29 | — | — | EP | disclosed |
| EP-2780039-A2 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | Pfizer Inc (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013072813-A2 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER INC. (US) | 2013-05-23 | — | — | WO | disclosed |